2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154508
    FdUMP triethylammonium
    		99.96%
    FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
    FdUMP triethylammonium
  • HY-90006S
    5-Fluorouracil-d
    		Inhibitor 99.42%
    5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-d
  • HY-77644
    5'-Deoxy-5'-iodouridine
    5'-Deoxy-5'-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-Deoxy-5'-iodouridine
  • HY-138614
    5'-O-DMT-2'-O-TBDMS-Ac-rC
    		99.80%
    5'-O-DMT-2'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-2'-O-TBDMS-Ac-rC
  • HY-107372S
    Uridine triphosphate-13C9,15N2 sodium
    Uridine triphosphate-13C9,15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
    Uridine triphosphate-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>2</sub> sodium
  • HY-138598
    5'-O-TBDMS-dG
    		98.83%
    5'-O-TBDMS-dG is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-TBDMS-dG
  • HY-138607
    5'-O-DMT-N2-DMF-dG
    		99.09%
    5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-DMT-N2-DMF-dG
  • HY-B0228S8
    Adenosine-d-2
    		99.72%
    Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
    Adenosine-d-2
  • HY-W394106
    5-Hydroxymethyl uridine
    		≥98.0%
    5-Hydroxymethyl uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Hydroxymethyl uridine
  • HY-13770
    Troxacitabine
    		99.95%
    Troxacitabine is nucleoside analog with potent anticancer activity.
    Troxacitabine
  • HY-W013728
    1,3,5-Tri-O-benzoyl-a-D-ribofuranose
    		99.75%
    1,3,5-Tri-O-benzoyl-a-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,3,5-Tri-O-benzoyl-a-D-ribofuranose
  • HY-45492
    DMT-2'Fluoro-DG(IB) Amidite
    		99.45%
    DMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside that can be used in the preparation of 4'-modified 2'-deoxy-2'-fluorouridine.
    DMT-2'Fluoro-DG(IB) Amidite
  • HY-113225S3
    Guanosine triphosphate-15N5 dilithium
    Guanosine triphosphate-15N5 (GTP-15N5) dilithium is 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-<sup>15</sup>N<sub>5</sub> dilithium
  • HY-A0004R
    Decitabine (Standard)
    Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.
    Decitabine (Standard)
  • HY-125818S3
    Cytidine-5'-triphosphate-13C9 dilithium
    		99.0%
    Cytidine-5'-triphosphate-13C9 (Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
    Cytidine-5'-triphosphate-<sup>13</sup>C<sub>9</sub> dilithium
  • HY-W578275
    3′-O-Methylcytidine
    		≥98.0%
    3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3′-O-Methylcytidine
  • HY-W010706
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
    		99.55%
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA.
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
  • HY-W011079
    5-Iodouridine
    		99.93%
    5-Iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Iodouridine
  • HY-W008048
    2',3'-O-Isopropylideneadenosine
    		99.97%
    2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2',3'-O-Isopropylideneadenosine
  • HY-N7517
    Adenosine 5′-monophosphoramidate sodium
    Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP.
    Adenosine 5′-monophosphoramidate sodium