2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1908):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-50071
    6-Amino-5-nitropyridin-2-one
    		Chemical
    6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
    6-Amino-5-nitropyridin-2-one
  • HY-W013259
    6-Methylmercaptopurine riboside
    		99.88%
    6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-Methylmercaptopurine riboside
  • HY-W012313
    2,2'-Anhydrouridine
    		99.50%
    2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog. 2,2'-Anhydrouridine is an important intermediate in the synthesis of other nucleoside-related compounds.
    2,2'-Anhydrouridine
  • HY-110407
    2'-O,4'-C-Methyleneadenosine
    2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.
    2'-O,4'-C-Methyleneadenosine
  • HY-16445B
    CNDAC hydrochloride
    		98.01%
    CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.
    CNDAC hydrochloride
  • HY-131795
    2-Methylthioadenosine
    		98.82%
    2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Methylthioadenosine
  • HY-138579
    2'-OMe-G(ibu) Phosphoramidite
    		99.42%
    2'-OMe-G(ibu) Phosphoramidite (DMT-2'-O-Methyl-rG(ib) Phosphoramidite) is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis.
    2'-OMe-G(ibu) Phosphoramidite
  • HY-W357137
    L-Threonolactone
    		98.0%
    L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    L-Threonolactone
  • HY-134324
    8-Hydroxyadenosine
    		99.86%
    8-Hydroxyadenosine is a purine nucleoside.
    8-Hydroxyadenosine
  • HY-W022290
    5-Bromocytidine
    5-Bromocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Bromocytidine
  • HY-W014306
    2',3'-Dideoxyuridine
    		99.89%
    2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-Dideoxyuridine
  • HY-B0158S
    Cytidine-d2
    		Chemical 99.86%
    Cytidine-d2 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>2</sub>
  • HY-N0157R
    Orotic acid (Standard)
    		Chemical
    Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.
    Orotic acid (Standard)
  • HY-W012293
    3'-Deoxycytidine
    		98.0%
    4-Amino-1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (3'-Deoxycytidine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3'-Deoxycytidine
  • HY-N0157A
    Orotic acid zinc
    		Chemical 99.84%
    Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.
    Orotic acid zinc
  • HY-W008849
    DMT-dC(bz) Phosphoramidite
    		99.44%
    DMT-dC(bz) Phosphoramidite is a deoxycytidine phosphoramide monomer with a protective group. DMT-dC(bz) Phosphoramidite is commonly used for synthesizing DNA dimers or trimers.
    DMT-dC(bz) Phosphoramidite
  • HY-W128112
    1-(a-D-ribofuranosyl)uracil
    1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(a-D-ribofuranosyl)uracil
  • HY-77652
    Nucleoside-Analog-2
    Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Nucleoside-Analog-2
  • HY-138585
    DMT-dG(dmf) Phosphoramidite
    		99.71%
    DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides
    DMT-dG(dmf) Phosphoramidite
  • HY-145791
    Dideoxycytidinene
    		98.36%
    Dideoxycytidinene (2′,3′-Didehydro-2′,3′-dideoxycytidine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Dideoxycytidinene